1. Post-doctoral Research Associate at the Mount Sinai School of Medicine, New York City, USA (2006-2008).
2. Ph.D. from CSIR NEIST Jothat, Assam (2006)
3. M.Sc. (Organic Chemistry) from Dibrugarh University, Assam (2001)
4. B.Sc. (Chemistry Hons.) from Govt. Science College, Jorhat, Assam (1998)

Employment:

1. Professor I, Institute of Advanced Study in Science and Technology (IASST), Guwahati, Assam, (January 2024 to till date).
2. Associate Professor II, Institute of Advanced Study in Science and Technology (IASST), Guwahati, Assam, (October 2018 to December 2023).
3. Principal Scientist, CSIR-North East Institute of Science and Technology, Jorhat, Assam (CSIR-NEIST) (March 2016 to October 2018).
4. Scientist-C, Institute of Bioresources and Sustainable Development (IBSD), Takyelpat, Imphal, Manipur (October 2012 – March 2016)
5. Principal Scientist (R&D), Phyto Biotech Pvt. Ltd. Salt Lake City, Kolkata, West Bengal (Jan. 2012- Sep. 2012)
6. Sr.Research Scientist, Guwahati Biotech Park Incubation Centre, Technology Complex: IIT Guwahati, Assam (Jan 2009 – Dec. 2011)
7. Post-doctoral Research Associate at the Mount Sinai School of Medicine, New York City, USA (Nov. 2006 – Nov. 2008)
8. Research Scientist, Chemgen Pharam Int. Pvt. Ltd., Salt Lake City, Kolkata, West Bengal (Aug. 2005 – Sep. 2006)

Corresponding and First Author:

1. Pranamika Sarma, Bhaswati Kashyap, Shalini Gurumayum, Srutishree Sarma, Paran Baruah, Deepsikha Swargiary, Abhipsa Saikia, Ramesh Ch. Deka, Jagat C. Borah (2024). Antihyperglycemic Potential of Quercetin-3-glucoside Isolated from Leucaena leucocephala Seedpods via the SIRT1/AMPK/GLUT4 Signaling Cascade. ACS Omega. https://doi.org/10.1021/acsomega.3c09672
2. Devi Basumatary, Bhaswati Kashyap, Plabita Baruah, Jagat C. Borah (2024). Prophylactic    function of Garcinia morella dried fruits in preventing intestinal barrier disruption by lowering tight junction permeability and inflammation.  Food Bioscience, 57, 103408. https://doi.org/10.1016/j.fbio.2023.103408.
3. Deepsikha Swargiary,Bhaswati Kashyap, Pranamika Sarma, SemimAkhtar Ahmed, Shalini Gurumayum, Sagar Ramrao Barge, Devi Basumatary, Jagat C. Borah (2024). Free radical scavenging polyphenols isolated from Phyllanthus niruri L. ameliorates hyperglycemia via SIRT1 induction and GLUT4 translocation in in vitro and in vivo models.Fitoterapia,105803.https://doi.org/10.1016/j.fitote.2023.105803
4. Semim Akhtar Ahmed, Pranamika Sarma, Sagar Ramrao Barge, Deepsikha Swargiary, Gurumayum Shalini Devi, Jagat Chandra Borah (2023). Xanthosine, a purine glycoside mediates hepatic glucose homeostasis through inhibition of gluconeogenesis and activation of glycogenesis via regulating the AMPK/ FoxO1/AKT/GSK3β signaling cascade. Chemico-Biological Interactions, 371, 110347. DOI: 10.1016/j.cbi.2023.110347
5. Shalini Gurumayum, Simanta Bharadwaj, Yunus Sheikh, Sagar R. Barge, Kangkon Saikia, Deepsikha Swargiary, Semim Akhtar Ahmed, Debajit Thakur, Jagat C. Borah (2023). Taxifolin-3-O-glucoside from Osbeckia nepalensis mediates antihyperglycemic activity in CC1 hepatocytes and in diabetic Wistar rats via regulating AMPK/G6Pase/PEPCK signaling axis. Journal of Ethnopharmacology, 303, 115936.  DOI: 10.1016/j.jep.2022.115936 
6. Bhaswati Kashyap, Kangkon Saikia, Suman Kumar Samanta, Debajit Thakur, Sanjay Kumar Banerjee, Jagat Chandra Borah, Narayan Chandra Talukdar (2023). Kaempferol 3-O-rutinoside from Antidesma acidum Retz. stimulates glucose uptake through SIRT1 overexpression followed by GLUT4 translocation in skeletal muscle L6 cells. Journal of Ethnopharmacology, 301, 115788. https://doi.org/10.1016/j.jep.2022.115788
7. Barsha Deka, Pranamika Sarma, Prasenjit Manna, Jagat Chandra Borah, Narayan Chandra Talukdar (2023). Alliin enriched standardized fraction of Allium hookeri regulates the glucose homeostasis via upregulating hepatic glutathione pool. Phytomedicine Plus 3, 100466. https://doi.org/10.1016/j.phyplu.2023.100466
8. Pranamika Sarma, Simanta Bharadwaj, Deepsikha Swargiary, Semim Akhtar Ahmed, Yunus Sheikh, Sagar Ramrao Barge, Prasenjit Manna, Narayan Chandra Talukdar, Jayanta Bora, Jagat Chandra Borah (2022). Iridoid glycoside isolated from Wendlandia glabrata and the role of its enriched fraction in regulating AMPK/PEPCK/G6Pase signaling pathway of hepatic gluconeogenesis. New J. Chem. https://doi.org/10.1039/D1NJ05856H
9. Simanta Bharadwaj, Gurumayum Shalini Devi, Pranamika Sarma, Barsha Deka, Sagar Ramrao Barge, Bhaswati Kashyap, Prasenjit Manna, Jagat C. Borah, Narayan Chandra Talukdar (2022). Prophylactic role of Premna herbacea, a dietary leafy vegetable in managing hepatic steatosis via regulating AMPK/SREBP1/ACC/HMGCR signaling pathway. Food Bioscience, 48, 101720. 10.1016/j.fbio.2022.101720
10. Barsha Deka, Prasenjit Manna, Jagat Chandra Borah, Narayan Chandra Talukdar (2022). A review on phytochemical, pharmacological attributes and therapeutic uses of Allium hookeri. Phytomedicine Plus, 100262. https://doi.org/10.1016/j.phyplu.2022.100262  
11. AK Borah, Semim A Ahmed and JC Borah (2022). Phytomedicine as a source of SGLT2 inhibitors, GLP-1 secretagogues and DPP-IV inhibitors for mitigation of Diabetic Nephropathy. Phytomedicine Plus, 100225.       https://doi.org/10.1016/j.phyplu.2022.100225
12. Sagar Barge, Barsha Deka, Bhaswati Kashyap, Simanta Bharadwaj, Raghuram Kandimalla, Aparajita Ghosh, Partha Pratim Dutta, Suman Kumar Samanta, Prasenjit Manna, Jagat C. Borah, Narayan Chandra Talukdar (2021). Astragalin mediates the pharmacological effects of Lysimachia candida Lindl on adipogenesis via downregulating PPARG and FKBP51 signaling cascade. Phytotherapy Research 2021, 1-14. DOI: 10.1002/ptr.7320
13. Bhaswati Kashyap, Sagar Ramrao Barge, Simanta Bharadwaj, Barsha Deka, Seydur Rahman, Aparajita Ghosh, Prasenjit Manna, Partha Pratim Dutta, Yunus Sheikh, Raghuram Kandimalla, Suman Kumar Samanta, Joshodeep Boruwa, Shilpi Saikia, Deepsikha Swargiary, Parul Kamboj, Deepika Tuli, Uttam Pal, Jagat C. Borah, Sanjay Kumar Banerjee, Narayan Chandra Talukdar (2021). Evaluation of therapeutic effect of Premna herbacea in diabetic rat and isoverbascoside against insulin resistance in L6 muscle cells through bioenergetics and stimulation of JNK and AKT/mTOR signaling cascade. Phytomedicine 93, 153761. DOI: 10.1016/j.phymed.2021.153761
14. Anuj Kumar Borah, Pranamika Sharma, Archana Singh, Kangkan Jyoti Kalita, Sougata Saha, and Jagat Chandra Borah (2021). Adipose and non-adipose perspectives of plant derived natural compounds for mitigation of obesity. Journal of Ethnopharmacology. 280, 114410. PMID: 34273447. DOI: 10.1016/j.jep.2021.114410
15. Sagar Barge, Dhananjay Jade, Gokul Gosavi, Narayan C Talukdar, Jagat C Borah (2021). In-silico screening for identification of potential inhibitors against SARS-CoV-2 transmembrane serine protease 2 (TMPRSS2). European Journal of Pharmaceutical Sciences, 162, 105820. PMID: 33775827. DOI: 10.1016/j.ejps.2021.105820
16. Yunush Sheikh, Maibam Beebina Chanu, Gopinath Mondal, Prasenjit Manna, Asamanja Chattoraj, Dibakar Chandra Deka, Narayan Chandra Talukdar and Jagat Chandra Borah (2019). Procyanidin A2, an anti-diabetic condensed tannin extracted from Wendlandia glabrata, reduces elevated G-6-Pase and mRNA levels in diabetic mice and increases glucose uptake in CC1 hepatocytes and C1C12 myoblast cells. RSC Adv., 9, 17211. DOI: 10.1039/C9RA02397F
17. Sheikh, Y., Chanu, M. B., Talukdar, N.C., Deka, D., Borah, J.C. (2016). In vitro and in vivo anti-diabetic and hepatoprotective effects of edible pods of Parkia roxburghii and quantification of the active constituent by HPLC-PDA. Journal of Ethnopharmacology. 191, 21-28. PMID: 27282664. DOI: 10.1016/j.jep.2016.06.015
18. Laisharm, S., Sheikh, Y., Moirangthem, D.S., Deb, L., Pal, B.C., Talukdar, N.C., Borah, J.C. (2015). Anti-diabetic molecules from Cycas pectinata Griff. traditionally used by the Maiba-Maibi. Phytomedicine. 22, 23-26. PMID: 25636866. DOI: 10.1016/j.phymed.2014.10.007
19. Sheikh, Y., Chanu, M. B., Biswas, D., Laisharm, S., Deb, L., Talukdar, N.C., Borah, J.C. (2015).  Anti-diabetic potential of selected ethnomedicinal plants of North East India. Journal of Ethnopharmacology. 171, 37-41. PMID: 26023028. DOI: 10.1016/j.jep.2015.05.030
20. Jagat C Borah (2015). Shikimic acid: a highly prospective molecule in pharmaceutical industry. Current Science. 109, 1672-1679.
21. Jagat Borah, Shiraz Mujtaba, Ioannis Karakikes, Lei Zeng, Michaela Muller, Roger J. Hajjar, & Ming-Ming Zhou (2011). A Small Molecule Binding to the Co-activator CREB-Binding Protein Blocks Apoptosis in Ischemic Cardiomyocytes. Chemistry & Biology. 2011, 18, 531-541. PMID: 21513889. DOI: 10.1016/j.chembiol.2010.12.021
22. Borah, J. C.; Boruwa, J.; Barua, N. C. Review Article: “Synthesis of the C-13 Side Chain of  Taxol”. Current Organic Synthesis. 2007, 4, 175-199.
23. Borah, J. C., Boruwa, J., Barua, N. C. Stereoselective total synthesis of (+)-Sedamine. Letters In Organic Chemistry. 2006, 3, 140-142.
24. Borah, J. C., Gogoi, S., Boruwa, J., Barua, N. C. LaCl₃.7H₂O Promoted Regioselective Ring Opening of Epoxides Using NaNO₂ in Ether-Water System: A Facile Synthesis of 2- nitroalcohols. Synthetic Communication. 2005, 35, 873 – 878.
25. Borah, J. C., Gogoi, S., Boruwa, J., Kalita, B., Barua, N. C. A highly efficient synthesis of the C-13 side-chain of taxol using Shibasaki’s asymmetric Henry Reaction. Tetrahedron Letters. 2004, 45, 3689-3691.

Co-author: Phytochemistry, synthetic and medicinal chemistry

1. Dipak Biswas, Bharat Gopalrao Somkuwar,  Jagat Chandra Borah, Pritish Kumar Varadwaj Saurabh Gupta, Zeeshan Ahmad Khan, Gopinath Mondal, Asamanja Chattoraj and Lokesh Deb (2023). Phytochemical mediated modulation of COX-3 and NFκB for the management and treatment of arthritis. Sci Rep 13, 13612. https://doi.org/10.1038/s41598-023-37729-2
2. Dipika Konwar, Pranamika Sarma, Jagat Chandra Borah and Utpal Bora (2023). Halogen bonding assisted site-selective C-3 triaryl methylation of indoles and N-triaryl methylation of imidazoles, Organic & Biomolecular Chemistry. DOI: 10.1039/d3ob00783a
3. Md Jahangir Alam^, Parul Kamboj, Soumalya Sarkar, Sonu Kumar Gupta, Siva Swapna Kasarla, Sneh Bajpai, Deepika Kumari, Neema Bisht, Sagar Ramrao Barge, Bhaswati Kashyap, Barsha Deka, Simanta Bharadwaj, Seydur Rahman, Partha Pratim Dutta, Jagat C Borah, Narayan Chandra Talukdar, Yashwant Kumar, Sanjay K Banerjee (2023). Untargeted metabolomics and phenotype data indicate the therapeutic and prophylactic potential of Lysimachia candida Lindl. towards high-fat high-fructose-induced metabolic syndrome in rats. Molecular Omics, DOI: 10.1039/d3mo00104k
4. Dev Madhubala, Aparup Patra, Taufikul Islam, Kangkon Saikia, Mojibur R. Khan, Semim Akhtar Ahmed, Jagat C. Borah, Ashis K. Mukherjee (2023). Snake venom nerve growth factor-inspired designing of novel peptide therapeutics for the prevention of paraquat-induced apoptosis, neurodegeneration, and alteration of metabolic pathway genes in the rat pheochromocytoma PC-12 cell, Free Radical Biology and Medicine, DOI: 10.1016/j.freeradbiomed.2023.01.019
5. Rajkumari Mazumdar; Partha Pratim Dutta; Juri Saikia; Jagat Chandra Borah; Debajit Thakur (2023). Streptomyces sp. Strain PBR11, a Forest-Derived Soil Actinomycetia with Antimicrobial Potential. Microbiology Spectrum. DOI: 10.1128/spectrum.03489-22
6. Aditya Narayan Konwar, Surajit Basak, Shalini Gurumayum Devi, Jagat Chandra Borah, Debajit Thakur (2023). Streptomyces sp. MNP32, a forest‑dwelling Actinomycetia endowed with potent antibacterial metabolites. 3 Biotech (2023) 13:257.        https://doi.org/10.1007/s13205-023-03670-4
7. Sagar Bargea,b , Dhananjay Jadec , Selvaraj Ayyamperumalc , Prasenjit Mannaa , Jagat Boraha , Chandrasekar Moola Joghee Nanjanc , Moola Joghee Nanjand and Narayan Chandra Talukdara (2021). Potential inhibitors for FKBP51: an in silico study using virtual screening, molecular docking and molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics, https://doi.org/10.1080/07391102.2021.1994877
8. Barsha Deka, Sagar Barge, Simanta Bharadwaj,  Bhaswati Kashyap, Prasenjit Manna, Jagat C Borah, Narayan Chandra Talukdar (2021). Beneficial effect of the methanolic leaf extract of Allium hookeri on stimulating glutathione biosynthesis and preventing impaired glucose metabolism in type 2 diabetes. Archives of Biochemistry and Biophysics, 708, 108961. DOI: 10.1016/j.abb.2021.108961
9. Parul Kamboj, Soumalya Sarkar, Sonu Kumar Gupta, Neema Bisht, Deepika Kumari, Sagar Barge, Bhaswati Kashyap, Barsha Deka, Simanta Bharadwaj, Seydur Rahman, Partha Pratim Dutta, Jagat C Borah, Narayan Chandra Talukdar, Sanjay Kumar Banerjee, Yashwant Kumar (2021). Methanolic extract of Lysimachia candida Lindl. prevents high-fat-high-fructose-induced fatty liver in rats: Understanding the molecular mechanism through untargeted metabolomics study. Frontiers in Pharmacology, 12, Article 653872. DOI: 10.3389/fphar.2021.653872
10. Indranirekha Saikia, Moushumi Hazarika, Sheik Yunus, Mintu Pal, Manash R Das, Jagat C Borah and Chandan Tamuly (2018). Green synthesis of Au-Ag-In-rGO nanocomposite and its α-glucosidase and cytotoxicity effects. Material Letters. 2018, 211, 48-50.
11. Devi, S.I., Lotjem, H., Devi, E.J., Potshangbam, M., Ngashangva, N., Borah, J., Sahoo, D., Sharma, C. (2017). Bio-mining the forest ecosystem of North East India for identification of antimicrobial metabolites from fungi through submerged fermentation. Bioresource Technology. 241, 1168-1172 PMID: 28578806.
12. Buragohain, P., Surineni, N., Barua, N. C., Bhuyan, P. D., Boruah, P., Borah, J. C., Laisharm, S., Moirangthem, D.S. (2015). Synthesis of a novel series of Fluoroarene derivatives of Artemisinin as potent antifungal and anticancer agent. Bioorganic & Medicinal Chemistry Letter. 2015, 25, 3338-3341. PMID: 26099535.
13. L. Surbala, M. D. Singh, J. C. Borah, M. C. Kalita, N. C. Talukdar. (2015). Chrysin rich Scutellaria discolour Colebr. Induces cervical cancer cell death via induction of arrest and caspase dependent apoptosis. Life Sciences. 143, 105-113. PMID: 26541229.
14. D. Singh, L. Surbala, V.S Rana, J. C. Borah, N. C. Talukdar. Essential oil of Cephalotaxus griffithii needle inhibits proliferation and migration of human cervical cancer cells: involvement of mitochondria-initiated and death receptor-mediated apoptosis pathways. Natural Product Research. 2015, 29, 1161-1165. PMID: 25426576.
15. D. Singh, L. Surbala, J. C. Borah, M. C. Kalita, N. C. Talukdar. Cephalotaxus griffithii Hook.f. needle extract induces cell cycle arrest, apoptosis and suppression of hTERT and hTR expression on human breast cancer cells. BMC Complementary and Alternative Medicine. 2014, 14:305. PMID: 25135691.
16. M. D. Singh, J. C. Borah, L. Surbala, M. C. Kalita, N. C. Talukdar. HPLC analysis of harringtonine and homoharringtonine in the needles of Cephalotaxus griffithii alkaloid fraction and cytotoxic activity on chronic myelogenous leukaemia K562 cell. Natural Product Research. 2014, 28 (18): 1503-6. PMID: 24787645.
17. Gogoi, N.; Borah, J. C.; Boruwa, J.; Barua, N. C. Lipase Catalyzed Kinetic Resolution of 2-Nitroalcohol: Total Synthesis of Taxol Side Chain and (-)-Bestatin. Letters In Organic Chemistry. 2007, 4, 234-235.
18. Boruwa, J., Borah, J. C., Gogoi, S., Barua, N. C. A short asymmetric total synthesis of chloramphenicol using a selectively protected 1, 2-diol. Tetrahedron Letters. 2005, 46, 1743 – 1746.
19. Boruwa, J., Borah, J. C., Kalita, B., Barua, N. C. Highly regioselective ring opening of epoxides using NaN₃: a short and efficient synthesis of (-)- Cytoxazone. Tetrahedron Letters. 2004, 45, 7355-7358.
20. Gogoi, S., Borah, J. C., Barua, N. C. Montmorillonite K-10 Clay as an Efficient Solid Catalyst for Chemoselective Protection of Carbonyl Compounds as Oxathiolanes with 2- mercaptoethanol. Synlett. 2004, 1592-1594.
21. Boruwa, J., Kalita, B., Barua, N. C., Borah, J. C., Mazumdar, S., Thakur, D., Gogoi. Synthesis, absolute stereochemistry and molecular design of the new antifungal and antibacterial antibiotic produced by streptomyces sp.201.  Bioorganic & Medicinal Chemistry Letters. 2004, 14, 3571-3574. PMID: 15177476.

Book Chapters:

1. Book: High-Value Plants: Novel Insights and Biotechnological Advances. Chapter 4: Genus Garcinia in Northeast India: Folklore Applications, Scope, and Opportunities. Authors: Bora J. C. and Joshi D. D., Publisher: CRC Press, Taylor & Francis Group, Hard ISBN: 9781774913116, Year:2022 (online).
2. Book: Potent Anticancer Medicinal Plants: Secondary Metabolite Profiling, Active Ingredients, and Pharmacological Outcomes. Chapter 9: Panax ginseng. Authors: Shalini Gurumayum, Sagar Barge, and Jagat C. Borah, Publisher: CRC Press, Taylor & Francis Group, Hard ISBN: 9781774913116, Year:2022 (online).

3. Serine Proteases: Role in Human Health and Disease. Chapter 5:  Inhibition of the serine exopeptidase DPP-IV as a means of mitigation of diabetic nephropathy. Authors: SA Ahmed, AK Borah, JC Borah. Year: 2023. Walter de Gruyter GmbH, Berlin/Boston, 2023, pp. 65-82. https://doi.org/10.1515/9783111325040-005

Patent:

Granted:

1. Rajashekar and JC Borah. A biofumigant comprising 2-methyltetrahydro-3-furanone. Patent (IP) No. 439446. Date of grant 19-07-2023.
2.  JC Borah et al. Herbal Formulation for Prevention of Type 2 Diabetes Mellitus and Conditions Associated Therewith. Patent (IP) No. Date of grant 26-06-2024. (Applicant IASST, Guwahati-35, Assam).

Filed:

1. Borah, Jagat Chandra; Mukherjee, Ashis K.; Sarma, Pranamika; Ahmed, Semim Akhtar; Devi, Basumatary; 2023. Method of preparation of enriched fraction from Boerhavia diffusa for the treatment of diabetic nephropathy and related complications through Sodium Glucose Co-Transporter 2 (SGLT2) inhibition. Patent application number: 202331084709 filed on 12-12-2023.
2. Borah, Jagat Chandra; Borah, Utpal; Mukherjee, Ashis K.; Gurumayum, Shalini; Konwar,  Dipika; Sarma, Pranamika; 2023. Sodium Glucose Transporter 2 (SGLT2) Inhibitors and Process of Preparation. Patent application number: 202331029891.
3. Borah, Jagat Chandra; Mukherjee, Ashis K.; Ahmed, Semim Akhtar, Sarma, Pranamika; 2023. Method of preparation of enriched fraction from Tribulus terrestris for the treatment of diabetic nephropathy and related complications through Sodium Glucose Co -Transporter 2 (SGLT2) inhibition. Patent application number: 202331028160.
4. M. R. Khan, J. C. Borah, Y. Sheikh, S. Barge, R. Sagar, J. Bhattacharjee A. K. Mukherjee, 2023. Method of Preparation of Bioactive Fractions and Molecules with α-Glucosidase Inhibition Activity from the Plant Parkia Roxburghii. Application no. 202331004130.
5. M. R. Khan, J. C. Borah, Y. Sheikh, S. Barge, R. Sagar, J. Bhattacharjee A. K. Mukherjee, 2023. Method of Preparation of Bioactive Fractions and Molecules with α-Glucosidase Inhibition Activity from the Plant Eurya Acuminata. Application no.  202331004131.  
6.  A herbal composition from Premna herbacea, useful for prevention of Obesity and Type 2 diabetes and a method for its extraction (PCT/IN2019/050887, 2019 and WO 2020/115767 A1, 11 June 2020). 
7.  A herbal extraction from Lysimachia Candida for treatment of Obesity and related hyperglycemia and a method for its extraction (Application No.201931019887 A, 2019).
8. Inhibitors of bromodomains as modulators of gene expression (WO 2012116170 A1; PTC/US2012/026308)