Electrochemical sensing platform for detecting carcinogenic & mutagenic compounds in food

With the rising “foodie” community around the world, there is also a rise in different cuisine. People are indulging more in meat and alcohol products. Although these food suits our taste buds but they certainly are not very healthy for our health. Cured meats, bacon, some cheese, low fat dry milk and sometimes even fish can contain some harmful chemicals belonging to Nitrosamine family. These toxic chemicals may alter the chemical composition of our DNA leading to cancer. Using the ability of these chemicals, especially N-nitrosodimethylamine (NDMA) and N-nitrosodiethanolamine (NDEA), to alter the DNA, we developed an electrochemical sensing platform for them. The electrode was modified by depositing carbon dots (carbon nanoparticles) and then immobilizing bacterial DNA on them. Both NDMA and NDEA alters the chemical structure of DNA present in the electrode making it more conducting which ultimately results in the increase current peak hence its detection. The work published recently in DNA Carbon-​Nanodots based Electrochemical Biosensor for Detection of Mutagenic Nitrosamines, Majumdar, Sristi; Thakur, Debajit; Chowdhury, Devasish, ACS Applied Bio Materials, 2020, 3(3), 1796-1803. DOI:10.1021/acsabm.0c00073.