Dr. Sourav Das

Institute of Advanced Study in Science and Technology

Vigyan Path, Paschim Boragaon Garchuk,Guwahati, Assam 781035, India

Ph No.: +91-361-2270095, Ext-125.

Email: sourav[dot]das[at]iasst[dot]gov[dot]in

Google Scholar ORCID Biodata

Research Interest

  • Protein-Ligand interaction studies using spectroscopic techniques.
  • Protein fibrillation and glycation.
  • Emulsion gels
  • Cascade reactions in oil/water interface.
  • Nanozymes
  • Temporal control over enzymatic activities using vesicles/micelles.
  • Preparation of emulsion gels for dual drug delivery.
  • Liquid-liquid phase separation and coacervates.
  • Carbon dots for denitrosylation.
Google scholar (link): https://scholar.google.com/citations?user=ygN4NlwAAAAJ&hl=en

Research at a glance.......

                     Graphical abstract: Lysozyme–luteolin binding: molecular insights into the complexation process and the inhibitory effects of luteolin towards protein modification    Graphical abstract: Molecular recognition of bio-active flavonoids quercetin and rutin by bovine hemoglobin: an overview of the binding mechanism, thermodynamics and structural aspects through multi-spectroscopic and molecular dynamics simulation studies                     

Experience

  • May 2024- present: DST INSPIRE Faculty at IASST, Guwahati
  • Sep 2023-May 2024 Assistant professor, Department of Chemistry, The Assam Royal Global University.
  • 2021-23 DBT Postdoctoral fellow at IISc Bangalore
  • 2021 Ph.D., National Institute of Technology Meghalaya, Shillong, 793003
  • 2015 M.Sc., North Eastern Hill University, Umshing Mawkynroh, Shillong, Meghalaya.

Scholastic Achievements and awards

  • DST INSPIRE Faculty Award from the Department of Science and Technology (DST), India, March 2024.
  • Department of Biotechnology-Research associate (DBT-RA) fellowship, 2021.
  • Featured in the list of worlds top 2 % most cited student researcher in 2021 and 2025 database (published by Stanford University) https://elsevier.digitalcommonsdata.com/datasets/btchxktzyw/3 https://elsevier.digitalcommonsdata.com/datasets/btchxktzyw/3/files/b3e31af2-054c-4b3a-b9c5-6fd9bf10557a
  • SLET
  • CSIR UGC NET
  • Ranked 2nd (position) in M.Sc. (Chemistry), NEHU 2015.
  • Best poster award at the National Seminar on Recent Developments in Chemistry, July 12 -13, St. Mary’s college, Shillong, 2017.
  • Best poster award at the National Conference on Recent Advances in Chemistry, October 14 -15, NIT Meghalaya, Shillong, 2019.
  • Received the Institute Best Research Award, awarded by the National Institute of Technology Meghalaya at the Research Conclave, 2020 (https://nitm.ac.in/p/prize).
  • Indian Chemical Society Research Excellence Award for oral Presentation in international seminar on “Recent Advances in Chemistry & Material Sciences (2020)” held in the month of August 2020.
  • Received Best poster award from American Chemical Society at NCMMS 2022 held at VIT Bhopal University, Feb 28-March 02, 2022.

Journal Publications

  1. Kakali Baruah, Ajit Kumar Singh, Sourav Das, Sweta Sucharita Sahoo, Kalpana Kumari, Anupam Nath Jha, Atanu Singha Roy. Common Nefafu (Clerodendrum colebrookianum L.)-Mediated Silver Nanoparticles for Physicochemical Insights into the Protein Corona Formation and Inhibition of Fibrillation of Human Serum Albumin. Langmuir 2025, 41, 35, 23405–23422. 10.1021/acs.langmuir.5c02195
  2. Srivastava, P. Kumar, M. Punugusamy ,S. Das and S. Rana. Adaptive Catalytic Compartments Emerge from Synergistic Integration of DNA Nanostructure and Transient Coacervate,     Nanoscale Horiz., 2025,10, 3319-3329 DOI :10.1039/D5NH00519A
  3. M. Solra#, S. Das#, S. Nayak, A. Srivastava, R. Kapila, S. I. Chaudhury, S. Rana, Multivalent Amine Functionalized Carbon Dots Catalyze Efficient Denitrosylation. ChemCatChem 2024, e202401338. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cctc.202401338
    (Equal first authorship)
  4. Sarma, J; Rajkhowa, S; Das, S. Synthesis of White Silica From “Joha Rice Husk” (A Special Rice Variety of Assam, India), Characterization and Determination of Its Point of Zero Charge (pHPZC), Journal of Chemistry, 2024, 554285. https://onlinelibrary.wiley.com/doi/10.1155/joch/5542855
  5. Das, S; Nudrat, S; Maity, S; Jana, M; Belwal, VK; Singha Roy, A. Isoflavones and lysozyme interplay: Molecular insights into binding mechanisms and inhibitory efficacies of isoflavones against protein modification. Chemical Physics Impact. 8, 100643, 2024. https://www.sciencedirect.com/science/article/pii/S2667022424001877
  1. Solra, M; Kapila, R; Das, S; Rana, S. Transient metallo-lipidoid assemblies amplify covalent catalysis of aqueous and non-aqueous reactions. Angew. Chem. Int. Ed. 63, e202400348, 2024. https://onlinelibrary.wiley.com/doi/10.1002/anie.202400348
  1. Solra, M; S, Fathima; Das,S; Kapila,R; Chaudhury,S.I; Rana, S; Robust and multifunctional wetting-resistance of de novo engineered non-fluorinated metal-organic nanocrystals for environmental sustainability. Advanced Engineering Materials. 26, 2301740, 2024.https://onlinelibrary.wiley.com/doi/full/10.1002/adem.202301740
  1. Solra, M; Das, S; Rana, S. Point-of-care detection of hydroxyurea drug in serum using a supramolecular enzyme mimetic. Sensors and Actuators B: Chemical, 406, 135424, 2024. https://www.sciencedirect.com/science/article/pii/S0925400524001539
  1. Das, S.; Solra, M.; Sahoo, J.; Srivastava, A.; S, Fathima.; De, M.; Rana, S. G-Quadruplex Hydrogel-Based Stimuli-Responsive High-Internal-Phase Emulsion Scaffold for Biocatalytic Cascades and Synergistic Antimicrobial Activity. Chemistry of Materials. 36, 2, 759–771,2023.https://pubs.acs.org/doi/10.1021/acs.chemmater.3c02173  Accepted as Front Cover of the issue (https://pubs.acs.org/toc/cmatex/36/2)

  1. Pathan J, Quraishi S, Das S, Monika, Chalana A , Sutradhar D, Adhikari S. Exploring benzene Ru(II) complexes of 2-subsitituted quinoline/napthyridine ligands: Synthesis, biomacromolecular binding and DFT investigations. Journal of Molecular Structure. 1295, 136690, 2024. https://www.sciencedirect.com/science/article/pii/S0022286023017805
  1. Kamra, Das, S; P. Bhatt, M. Solra, T. Maity, S. Rana, A Transient Vesicular Glue for Amplification and Temporal Regulation of Biocatalytic Reaction Networks. Chemical Science. 2023, 14, 9267-9282.https://pubs.rsc.org/en/content/articlehtml/2023/sc/d3sc00195d
  1. Das, S.; Solra,M.; Rana, S. Emulsion Gel: A Dual Drug Delivery Platform for Osteoarthritis Treatment. Regenerative Engineering and Translational Medicine. 9, 279–294, 2023 https://doi.org/10.1007/s40883-022-00282-x.
  1. Solra,M.; Das, S.; Srivastava, A.; Sen, B.; Rana, S. Temporally Controlled Multienzyme Catalysis Using a Dissipative Supramolecular Nanozyme. ACS Appl. Mater. Interfaces 2022, 14, 40, 45096–45109.https://doi.org/10.1021/acsami.2c08888.
  1. Das, S.; Sarmah, S.; Hazarika, Z.; Rohman, M. A.; Sarkhel, P.; Jha, A. N.; Roy, A. Singha. Targeting the Heme Protein Hemoglobin by (-)-Epigallocatechin Gallate and the Study of Polyphenol-Protein Association Using Multi-Spectroscopic and computational Methods. Phys. Chem. Chem. Phys. 2020, 22, 2212-2228. https://doi.org/10.1039/C9CP05301H.
  1. Das, S.; Sarmah, S.; Singha Roy, A. Monitoring Fluorescence Emission Behaviors of Dietary Polyphenols in a Serum Albumin Environment. New Journal of Chemistry 2020,44, 299-302.https://pubs.rsc.org/en/content/articlelanding/2020/nj/c9nj03938d
  1. Das, S.; Pahari, S.; Sarmah, S.; Rohman, M. A.; Paul, D.; Jana, M.; Singha Roy, A. Lysozyme-Luteolin Binding: Molecular Insights into the Complexation Process and the Inhibitory Effects of Luteolin towards Protein Modification. Phys. Chem. Chem. Phys. 2019, 21, 12649–12666. https://doi.org/10.1039/c9cp01128e.
  1. Das, S.; Khanikar, P.; Hazarika, Z.; Rohman, A.; Uzir, A.; Jha, A. N.; Singha Roy, A. Deciphering the Interaction of 5 , 7-Dihydroxyflavone with Hen-Egg-White Lysozyme through Multispectroscopic and Molecular Dynamics Simulation Approaches. ChemistrySelect 2018, 3 (17), 4911–4922. https://doi.org/10.1002/slct.201800280.
  1. Das, S.; Bora, N.; Rohman, M. A.; Sharma, R.; Jha, A. N.; Singha Roy, A. Molecular Recognition of Bio-Active Flavonoids Quercetin and Rutin by Bovine Hemoglobin: An Overview of the Binding Mechanism, Thermodynamics and Structural Aspects through Multi-Spectroscopic and Molecular Dynamics Simulation Studies. Phys. Chem. Chem. Phys. 2018, 20 (33), 21668–21684. https://doi.org/10.1039/C8CP02760A.
  1. Das, S.; Rohman, M. A.; Singha Roy, A. Exploring the Non-Covalent Binding Behaviours of 7-Hydroxyflavone and 3-Hydroxyflavone with Hen Egg White Lysozyme: Multi-Spectroscopic and Molecular Docking Perspectives. Photochem. Photobiol. B Biol. 2018, 180, 25–38. https://doi.org/10.1016/j.jphotobiol.2018.01.021.
  1. Das, S.; Karn, A.; Sarmah, R.; Rohman, M. A.; Koley, S.; Ghosh, P.; Singha Roy, A. Characterization of Non-Covalent Binding of 6-Hydroxyflavone and 5,7-Dihydroxyflavone with Bovine Hemoglobin: Multi-Spectroscopic and Molecular Docking Analyses. Photochem. Photobiol. B Biol. 2017, 178, 40–52.https://www.sciencedirect.com/science/article/pii/S1011134417308308
  1. Das, S.; Santra, S.; Rohman, M. A.; Ray, M.; Jana, M.; Singha Roy, A. An Insight into the Binding of 6-Hydroxyflavone with Hen Egg White Lysozyme: A Combined Approach of Multi-Spectroscopic and Computational Studies. Biomol. Struct. Dyn. 2018, 37, 4019-4034. https://doi.org/10.1080/07391102.2018.1535451.
  1. Das, S.; Ghosh, P.; Koley, S.; Singha Roy, A. Binding of Naringin and Naringenin with Hen Egg White Lysozyme: A Spectroscopic Investigation and Molecular Docking Study. Acta Part A Mol. Biomol. Spectrosc. 2018, 192, 211–221. https://doi.org/10.1016/j.saa.2017.11.015. 
  1. Sarmah, S.; Pahari, S.; Das, ; Belwal, V. K.; Jana*, M.; Singha Roy, A. Non-Enzymatic Glycation of Human Serum Albumin Modulates Its Binding Efficacy towards Bioactive Flavonoid Chrysin: A Detailed Study Using Multi-Spectroscopic and Computational Methods. J. Biomol. Struct. Dyn. 2020, 39, 476-492. https://doi.org/10.1080/07391102.2019.1711196.
  1. Das, , Sarmah,S; Lyndem, S, Singha Roy, A, An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study, J. Biomol. Struct. Dyn. 2020. 39, 3347-3357. https://doi.org/10.1080/07391102.2020.1763201.
  1. Das, S.; Hazarika, Z.; Sarmah, S.; Rohman, M.A.; Paul, D.; Jha, A.N; Singha Roy, A., Exploring the interaction of bioactive kaempferol with serum albumin, lysozyme and hemoglobin: A biophysical investigation using multi-spectroscopic, docking and molecular dynamics simulation studies. Photochem. Photobiol. B Biol. 2020, 205, 111825.https://www.sciencedirect.com/science/article/pii/S1011134419309479
  1. Sarmah, S.,Das, , Singha Roy, A, Protective actions of bioactive flavonoids chrysin and luteolin on the glyoxal induced formation of advanced glycation end products and aggregation of human serum albumin: in vitro and molecular docking analysis, Intl. J. of Biological Macromolecules. 165, 2020, 2275-2285. https://doi.org/10.1016/j.ijbiomac.2020.10.023.
  1. Das, S., Langbang, L., Haque, M., Belwal, V. K., Aguan, K., Singha Roy, A*. Biocompatible silver nanoparticles: An investigation into their protein binding efficacies, anti-bacterial effects and cell cytotoxicity studies. Journal of Pharmaceutical Analysis, 11, 2021, 422-434. https://doi.org/10.1016/j.jpha.2020.12.003.
  1. Das, S., Singh, A., Samanta, S.K. et al.Naturally occurring anthraquinones as potential inhibitors of SARS-CoV-2 main protease: an integrated computational study. Biologia 77, 2022, 1121–1134.https://link.springer.com/article/10.1007/s11756-021-01004-4
  2. Baruah,K., Haque,M., Langbang,L., Das,S., Aguan, K., Singha Roy,A., Ocimum sanctum mediated green synthesis of silver nanoparticles: A biophysical study towards lysozyme binding and anti-bacterial activity, Journal of Molecular Liquids,337,2021, 116422. https://doi.org/10.1016/j.molliq.2021.116422.

Book Chapters

  1. Lyndem,S., Sarmah,S., Das, S., Singha Roy, A. Coumarin derivatives: biomedicinal properties and interactions with carrier proteins. Studies in Natural Products Chemistry, 73, 2022, 173-220. ISSN: 1572-5995
  2. Singha Roy, A., Sarmah, S, Das, S., Effects of Glycation on Serum albumin, in A Closer Look at Glycation, Nova Science publishers, 2021, pp 21-78. ISBN: 978-1-53619-176-9.
  3. Das, S., Jha, A.N. (2024). Role of Flavonoids as Ethnomedicine for the Treatment of Complex Neurodegenerative Diseases. In Traditional Resources and Tools for Modern Drug Discovery. Interdisciplinary Biotechnological Advances. Springer, Singapore. https://doi.org/10.1007/978-981-97-4600-2_11
  1. Coacervate Protocells-Nanoparticle (CopAu) Platform for Point-of-Care Detection of Cardiovascular Diseases.

Funding Agency: DST

Duration: 2024-2029

Fund: Rs 11200000

2. BioNanozyme-based Therapeutics for Cardiovascular Disease Treatment (BioNanoCVD)

Funding: IASST

Duration: 2025-2027

Fund: Rs. 600000

 

  1. Rana, S., Solra, M., Fathima S, Das, S. Mixed-Ligand Superhydrophobic Metal-Organic Frameworks, and the Process of Preparation Thereof. Application No.202241064733A, Patent No: 439252, Date of filing of Application :11/11/2022, Publication Date : 30/12/2022. Date of Patent granted: 17/07/2023.

Mr. Debabrat Goswami

(M.Sc. Chemistry)

Project Associate

DOJ: 20-02-2025

Coming soon....