Dr. Prasenjit Manna

Research Interest: Development of natural product (micronutrients, protein, small molecule) based affordable remedy package for the prevention of obesity, insulin resistance, vascular inflammation, type 2 diabetes, and CVD risk factors associated with metabolic syndrome.

Academic:

  • Doctor of Philosophy (2005-2010) (Molecular Medicine), Institution: Bose Institute, Kolkata, West Bengal, India
  • Master of Science (2003-2005) (Chemistry), Institution: Jadavpur University, Kolkata, West Bengal, India
  • Bachelor of Science (Chemistry), Institution: Jadavpur University, Kolkata, West Bengal, India

Employments:

  • Assistant Professor – II, Institute of Advance Study in Science and Technology, Guwahati, Assam, India (July, 2019-till date).
  • Ramalingaswami Re-Entry Fellow, CSIR-North East Institute of Science and Technology, Jorhat, Assam, India (CSIR-NEIST) (June, 2015-July, 2019).
  • Postdoctoral Fellow, LSU Health Sciences Center, Shreveport, LA, USA (November, 2010-May, 2015)

Fellowships:

  • Ramalingaswami Re-Entry Fellowship, Department of Biotechnology, Govt. of India (June, 2015-July, 2019).
  • Malcolm Feist Cardiovascular Research Fellowship, LSU Health Sciences Center Shreveport, LA, USA (December, 2011-December, 2014),
  • CSIR-Junior Research Fellowship, Govt. of India (October, 2005-October, 2010)
  • National Scholarship, Ministry of Human Resource Development, Govt. of India (1998-2005)

Award:

  • Fellow of the American College of Nutrition, 2015
  • Emerging Leader in Nutrition Science, American Society for Nutrition, Experimental Biology Annual Meeting, Boston, MA, USA, 2015
  • Best Poster Presentation Award, American Society for Nutrition, Experimental Biology Annual Meeting, San Diego, CA, USA, 2014
  • Postdoctoral Research Travel Award, American Society of Biochemistry and Molecular Biology, Experimental Biology Annual Meeting San Diego, CA, USA, 2014
  • Postdoctoral Research Travel Award, American Society of Biochemistry and Molecular Biology, Experimental Biology Annual Meeting Boston, MA, USA, 2013
  • Postdoctoral Research Travel Award, American Society of Biochemistry and Molecular Biology, Experimental Biology Annual Meeting San Diego, CA, USA, 2012
  • Best Oral Presentation Award, Delhi Pharmaceutical Sciences and Research University, Delhi, India, 2010

Dr. Manna has published 96 articles in peer-reviewed journals and has an H index of 42 (SCOPUS, January 2020).

List of publications:

  1. Dihingia A, Ozah D, Bora T, Kalita J, Manna P*. Gamma-glutamyl-carboxylated Gas6 mediates positive role of vitamin K on lowering hyperglycemia in type 2 diabetes. Annals of the New York Academy of Sciences 2019 (accepted) [Impact Factor: 4.295] [PMID: 31583710]
  2. Thakur N, Manna P*, Das J. Synthesis and biomedical applications of nanoceria, a redox active nanoparticle. Journal of Nanobiotechnology 2019,17:84. [Impact Factor: 5.345] [PMID: 31291944] (cited by 4 times)
  3. Bhatta A, Krishnamoorthy G, Marimuthu N, Dihingia A, Manna P, Biswal HT, Das M, Krishnamoorthy G. Chlorin e6 decorated doxorubicin encapsulated chitosan nanoparticles for photo-controlled cancer drug delivery. International Journal of Biological Macromolecules2019;136:951-961.[Impact Factor: 4.784] [PMID: 31226376] (cited by 1 times)
  4. Bordoloi J, Ozah D, Bora T, Kalita J, Manna P*. Gamma-glutamylcarboxylated Gas6 mediates the beneficial effect of vitamin K on lowering hyperlipidemia via regulating the AMPK/SREBP1/PPARα signaling cascade of lipid metabolism. Journal of Nutritional Biochemistry 2019,70:174-184. [Impact Factor: 4.490] [PMID: 31082594]
  5. Islam N, Dihingia A, Manna P, Das T, Kalita J, Dekaboruah HP, Saikia BK. Environmental and toxicological assessment of nanodiamond-like materials derived from carbonaceous aerosols. Science of the Total Environment 2019,679:209-220. [Impact Factor 5.589] [PMID: 31082594] (cited by 1 times)
  6. Sadhukhan P, Kundu M, Chatterjee S, Ghosh N, Manna P, Das J, Sil PC. Targeted delivery of quercetin via pH-responsive zinc oxide nanoparticles for breast cancer therapy. Materials Science and Engineering C: Materials for Biological Applications 2019,100:129-140. [Impact Factor 4.959] [PMID: 30948047] (cited by 10 times)
  7. Kundu M, Sadhukhan P, Ghosh N, Chatterjee S, Manna P, Das J, Sil PC. pH-responsive and targeted delivery of curcumin via phenylboronic acid-functionalized ZnO nanoparticles for breast cancer therapy. Journal of Advanced Research 2019,18:161–172 [Impact Factor 5.045] (cited by 5 times)
  8. Darabdhara⁠ G, Bordoloi J, Manna P, Das MR. Biocompatible bimetallic Au-Ni doped graphitic carbon nitride sheets: A novel peroxidase-mimicking artificial enzyme for rapid and highly sensitive colorimetric detection of glucose. Sensors & Actuators: B. Chemical 2019,285:277-290 [Impact Factor 6.393] (cited by 9 times)
  9. Gogoi K, Manna P, Dey T, Kalita J, Unni BG, Ozah D, Baruah PK. Circulatory heavy metals (cadmium, lead, mercury, and chromium) inversely correlate with plasma GST activity and GSH level in COPD patients and impair NOX4/Nrf2/GCLC/GST signaling pathway in cultured monocytes. Toxicology In Vitro 2019,54:269-279; [Impact Factor:3.067] [PMID: 30359721] (cited by 1 times)
  10. Das D, Sarkar S, Bordoloi J, Wann SB, Kalita J, Manna P*. Daidzein, its effects on impaired glucose and lipid metabolism and vascular inflammation associated with type 2 diabetes. BioFactors 2018,44:407-417[Impact Factor: 3.598][PMID: 30191632](cited by 7 times)
  11. Sen T, Neog K, Sarma S, Manna P, DekaBoruah HP, Gogoi P, Singh AK. Efflux pump inhibition by 11H-pyrido[2,1-b]quinazolin-11-one analogues in mycobacteria. Bioorganic and Medicinal Chemistry 2018,26:4942-4951. [Impact Factor: 2.802] [PMID: 30190182] (cited by 2 times)
  12. Dihingia A, Bordoloi J, Dutta P, Kalita J, Manna P*. Hexane-Isopropanolic Extract of Tungrymbai, a North-East Indian fermented soybean food prevents hepatic steatosis via regulating AMPK-mediated SREBP/FAS/ACC/HMGCR and PPARα/CPT1A/UCP2 pathways. Scientific Reports 2018,8:10021[Impact Factor: 4.011][PMID: 30190182] (cited by 4 times)
  13. Shingnaisui K, Dey T, Manna P, Kalita J. Therapeutic potentials of HouttuyniacordataThunb. against inflammation and oxidative stress: A review. Journal of Ethnopharmacology 2018;220:35-43.[Impact Factor:3.414] [PMID: 29605674] (cited by 10 times)
  14. Dewanjee S, Das S, Das AK, Bhattacharjee N, Dihingia A, Dua TK, Kalita J, Manna P*. Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets. European Journal of Pharmacology 2018,833:472-523. [Impact Factor:3.170] [PMID: 29966615] (cited by 16 times)
  15. Bordoloi J, Dihingia A, Kalita J, Manna P*. Implication of a novel vitamin K dependent protein, GRP/Ucma in the pathophysiological conditions associated with vascular and soft tissue calcification, osteoarthritis, inflammation, and carcinoma. International Journal of Biological Macromolecules 2018;113:309-316.[Impact Factor: 4.784] [PMID: 29499263](cited by 1 times)
  16. Dihingia A, Ozah D, Baruah PK, Kalita J, Manna P*. Prophylactic role of Vitamin K supplementation on vascular inflammation in type 2 diabetes by regulating NF-κB/Nrf2 pathway via activating Gla proteins. Food and Function 2018;9:450-462 [Impact Factor: 3.241] [PMID: 29227493](cited by 1 times)
  17. Manna P, Achari AE,Jain SK. 1,25(OH)2-Vitamin D3 upregulates glucose uptake mediated by SIRT1/IRS1/GLUT4 signaling cascade in C2C12 myotubes. Molecular and Cellular Biochemistry 2018,444:103-108[Impact Factor: 2.884][PMID: 29188534](cited by 2 times)
  18. Dihingia A, Ozah D, Ghosh S, Sarkar A, Baruah PK, Kalita J, Sil PC, Manna P*. Vitamin K1 Inversely Correlates with Glycemia and Insulin Resistance in Type 2 Diabetic (T2D) Patients and Positively Regulates SIRT1/AMPK Pathway of Glucose Metabolism in Liver of T2D Mice and Hepatocytes Cultured in High Glucose. Journal of Nutritional Biochemistry 2018;52:103-114 [Impact Factor:490] [PMID: 29175667](cited by 2 times)
  19. Das S, Joardar S, Manna P, Dua TK, Bhattacharjee N, Khanra R, Bhowmick S, Kalita J, Saha A, Ray S, De Feo V, Dewanjee S. Carnosic acid, a natural diterpene, attenuates arsenic-induced hepatotoxicity via reducing oxidative stress, MAPK activation, and apoptotic cell death pathway. Oxidative Medicine and Cellular Longevity 2018, 1421438. [Impact Factor:868][PMID: 29854073](cited by 1 times)
  20. Dey T, Dutta P, Manna P, Kalita J, Boruah HPD, Buragohain AK, Unni B. Anti-Proliferative activities of vasicinone on lung carcinoma cells mediated via activation of both mitochondria-dependent and independent pathways. Biomolecules and Therapeutics 2018,26:409-416. [Impact Factor: 2.656][PMID: 29310422]
  21. Dutta P, Dey T, Dihingia A, Manna P, Kalita J. Antioxidant and glucose metabolizing potential of edible insect, Brachytrupesorientalis via modulating Nrf2/AMPK/GLUT4 signaling pathway. Biomedicine and Pharmacotherapy 2017;95:556-563.[Impact Factor: 3.743][PMID: 28869893]
  22. Khanra R, Bhattacharjee N, Dua TK, Nandy A, Saha A, Kalita J, Manna P*, Dewanjee S. Taraxerol, a pentacyclictriterpenoid, from Abromaaugusta leaf attenuates diabetic nephropathy in type 2 diabetic rats. Biomedicine and Pharmacotherapy 2017; 94:726-741. [Impact Factor: 3.743] [PMID: 28802226](cited by 8 times)
  23. Dewanjee S, Joardar S, Bhattacharjee N, Dua TK, Das S, Kalita J, Manna P*. Edible leaf extract of Ipomoea aquaticaForssk. (Convolvulaceae) attenuates doxorubicin-induced liver injury via inhibiting oxidative impairment, MAPK activation and intrinsic pathway of apoptosis. Food and Chemical Toxicology 2017;105: 322-336[Impact Factor: 3.775] [PMID: 28478100](cited by 1 times)(cited by 5 times)
  24. Bharadwaz M, Manna P, Das D, Dutta N, Kalita J, Unni B, DekaBoruah HP. Isolation, Purification, and Characterization of Staphylocoagulase, a blood coagulating protein from Staphylococcus sp. MBBJP S43. International Journal of Biological Macromolecules 2017,102: 1312-1321 [Impact Factor: 4.784] [PMID: 28476593]
  25. Dihingia A, Kalita J, Manna P*. Implication of a novel Gla-containing protein, Gas6 in the pathogenesis of Insulin Resistance, Impaired Glucose Homeostasis, and Inflammation: A Review. Diabetes Research and Clinical Practice 2017;128:74-82 [Impact Factor: 3.239] [PMID: 28453960](cited by 3 times)
  26. Manna P, Achari AE, Jain SK. Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice. Archives of Biochemistry and Biophysics 2017;615:22-34. [Impact Factor: 3.559] [PMID: 28063949](cited by 23 times)
  27. Bhattacharjee N, Barma S, Konwar N, Dewanjee S, Manna P*. Mechanistic insight of diabetic nephropathy and its pharmacotherapeutic targets: An update. European Journal of Pharmacology 2016;791:8-24 [Impact Factor: 3.170] [PMID: 27568833](cited by 55 times)
  28. Manna P*, Kalita J. Beneficial role of vitamin K supplementation on insulin sensitivity, glucose metabolism, and the reduced risk of type 2 diabetes (T2D): A review. Nutrition 2016;32:732-739[Impact factor: 3.42] [PMID: 27133809](cited by 23 times)
  29. Dutta P, Dey T, Manna P, Kalita J. Antioxidant Potential of Vespa affinis L., a Traditional Edible Insect Species of North East India. PLoS One. 2016;11(5):e0156107. [Impact factor: 776](cited by 7 times)
  30. Dey T, Dutta P, Manna P, Kalita J, DekaBoruah HP, Buragohain AK, Unni BG, Ozah D, Goswami MK, Kotokey RK. Cigarette smoke compounds induce cellular redox imbalance, activate NF-κB, and increase TNF-α/CRP secretion: a possible pathway in the pathogenesis of COPD. Toxicology Research 2016;5:895-904. [Impact factor: 1.593](cited by 2 times)
  31. Manna P, Jain SK. Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies. Metabolic Syndrome and Related Disorders 2015;13:423-444. [PMID: 26569333][Impact factor: 1.597] (cited by 68 times)
  32. Manna P, Jain SK. Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes. Cellular Physiology and Biochemistry 2015;35:1253-1275. [PMID: 25721445][Impact factor: 5.5] (cited by 18 times)
  33. Manna P, Gungor N, McVieR,Jain SK. Decreased cystathionine-γ-lyase (CSE) activity in livers of type 1 diabetic rats and peripheral blood mononuclear cells (PBMC) of type 1 diabetic patients. Journal of Biological Chemistry 2014;289:11767-11778. [PMID: 24610811][Impact factor: 4.106] (cited by 23 times)
  34. Manna P, Jain SK.Effect of PIP3 on Adhesion Molecules and Adhesion of THP-1 Monocytes to HUVEC Treated with High Glucose. Cellular Physiology and Biochemistry 2014;33:1197-1204. [PMID: 24752192][Impact factor: 5.5] (cited by 9 times)
  35. Manna P, Jain SK. L-Cysteine and hydrogen sulfide increase PIP3 and AMPK/PPARγ expression and decrease ROS and vascular inflammation markers in high glucose treated human U937 monocytes. Journal of Cellular Biochemistry 2013;114:2334-2345. [PMID: 23733596][Impact factor: 3.448] (cited by 42 times)
  36. Manna P, Jain SK. PIP3 but not PIP2 increases GLUT4 surface expression and glucose metabolism mediated by AKT/PKCζ/λ phosphorylation in 3T3L1 adipocytes. Molecular and Cellular Biochemistry 2013;381:291-299.[PMID: 23749168][Impact factor: 2.884] (cited by 5 times)
  37. Bhattacharya S, Manna P, Gachhui R, Sil PC. D-Saccharic acid 1,4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-κB and PKC signaling. Toxicology and Applied Pharmacology 2013;267:16-29. [PMID: 23261973] [Impact factor: 3.585] (cited by 53 times)
  38. Manna P, Das J, Sil PC. Role of sulfur containing amino acids as an adjuvant therapy in the prevention of diabetes and its associated complications. Current Diabetes Reviews 2013;9:237-248. [PMID: 23547683][Impact factor: 1.62] (cited by 17 times)
  39. Manna P, Jain SK. Vitamin D upregulates glucose transporter 4 (GLUT4) translocation and glucose utilization mediated by cystathionine-γ-lyase (CSE) activation and H2S formation in 3T3L1 adipocytes. Journal of Biological Chemistry2012; 287:42324-42332. [PMID: 23074218][Impact factor: 4.106] (cited by 58 times)
  40. Jain SK, Manna P, Micinski D, Lieblong BJ, Kahlon G, Morehead L, Hoeldtke R, Bass PF 3rd, Levine SN. In African American Type 2 Diabetic Patients, Is Vitamin D Deficiency Associated with Lower Blood Levels of Hydrogen Sulfide and Cyclic Adenosine Monophosphate, and Elevated Oxidative Stress? Antioxidants and Redox Signaling 2012; 18:1154-1158. [PMID: 22852873] [Impact factor: 7.407] (cited by 18 times)
  41. Manna P, Jain SK. Decrease in hepatic phosphatidylinositol-3,4,5-triphosphate (PIP3) levels may be linked to impaired glucose homeostasis in type 1 and type 2 diabetic rats. Cellular Physiology and Biochemistry 2012;30:1363-1370. [PMID: 23108060] [Impact factor: 5.5] (cited by 16 times)
  42. Manna P,Sil PC. Impaired redox signaling and mitochondrial uncoupling contributes vascular inflammation and cardiac dysfunction in type 1 diabetes: Protective role of arjunolic acid. Biochimie 2012;94:786-797. [PMID: 22155371][Impact factor: 3.362] (cited by 29 times)
  43. Manna P,Ghosh M, Ghosh J, Das J, Sil PC. Contribution of nano copper particles to in vivo liver dysfunction and cellular damage: Role of IκBα/NF-κB, MAPKs and mitochondrial signal. Nanotoxicology 2012;6:1-21. [PMID: 21319953] [Impact factor: 5.955] (cited by 37 times)
  44. Manna P, Sil PC. Arjunolic Acid: Beneficial role in type 1 diabetes and its associated organ pathophysiology. Free Radical Research 2012;46:815-830. [PMID: 22486656][Impact factor: 2.825] (cited by 19 times)
  45. Pal PB, Pal S, Manna P, Sil PC. Traditional extract of Pithecellobiumdulce fruits protects mice against CCl(4) induced renal oxidative impairments and necrotic cell death. Pathophysiology 2012;19:101-114. [PMID: 22424982] (cited by 10 times)
  46. Das J, Ghosh J, Manna P, Sil PC. Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis. Amino Acids 2012;42:1839-1855. [PMID: 21476075][Impact factor: 2.520] (cited by 67 times)
  47. Manna P, Jain SK. Hydrogen sulfide and L-Cysteine increase PIP3 and glucose utilization by inhibiting PTEN and activating PI3K/ AKT/ PKCζ/λ in 3T3L1 adipocytes. Journal of Biological Chemistry2011; 286:39848-39859. [PMID: 21953448][Impact Factor: 4.106] (cited by 57 times)
  48. Manna P, Bhattacharyya S, Das J, Ghosh J, Sil PC. Phytomedicinal role of Pithecellobium dulce against CCl4-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. Evidence Based Complementary and Alternative Medicine 2011;2011:832805. [PMID: 21869899][Impact Factor: 1.984] (cited by 30 times)
  49. Sarkar A, Das J, Manna P, Sil PC. Nano-copper induces oxidative stress and apoptosis in kidney via both extrinsic and intrinsic pathways. Toxicology 2011;290:209-218. [PMID: 22000994] [Impact factor: 3.621] (cited by 62 times)
  50. Bhattacharya S, Manna P, Gachhui R, Sil PC. D-saccharic acid-1,4-lactone ameliorates alloxan-induced diabetes mellitus and oxidative stress in rats through inhibiting pancreatic beta-cells from apoptosis via mitochondrial dependent pathway. Toxicology and Applied Pharmacology 2011;257:272-283. [PMID: 21982801][Impact factor: 3.585] (cited by 26 times)
  51. Bhattacharya S, Chatterjee S, Manna P, Das J, Ghosh J, Gachhui R, Sil PC. Prophylactic role of D-saccharic acid-1,4-lactone in tertiary butyl hydroperoxide induced cytotoxicity and cell death of murine hepatocytes via mitochondria-dependent pathways. Journal of Biochemical and Molecular Toxicology 2011;25:341-354. [Impact Factor: 2.965] [PMID: 21538728](cited by 9 times)
  52. Datta P, Mukhopadhyay AP, Manna P, Tiekink ER, Sil PC, Sinha C. Structure, photophysics, electrochemistry, DFT calculation, and in-vitro antioxidant activity of coumarin Schiff base complexes of Group 6 metal carbonyls. Journal of Inorganic Biochemistry 2011;105:577-588. [PMID: 21419093] [Impact Factor: 3.224] (cited by 29 times)
  53. Bhattacharya S, Manna P, Gachhui R, Sil PC. Protective effect of kombucha tea against tertiary butyl hydroperoxide induced cytotoxicity and cell death in murine hepatocytes. Indian Journal of Experimental Biology 2011;49:511-524. [PMID: 21800502][Impact Factor: 0.934] (cited by 19 times)
  54. Das J, Ghosh J, Manna P, Sil PC. Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and inhibition of p53, p38-JNK. Biochemical Pharmacology 2011;81:891-909. [PMID: 21295553][Impact Factor: 4.825] (cited by 104 times)
  55. Ghosh M, Manna P, Sil PC. Protective role of a coumarin-derived schiff base scaffold against tertiary butyl hydroperoxide (TBHP)-induced oxidative impairment and cell death via MAPKs, NF-κB and mitochondria-dependent pathways. Free Radical Research 2011;45:620-637. [PMID: 21391895][Impact Factor: 2.825] (cited by 20 times)
  56. Ghosh J, Das J, Manna P, Sil PC. The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis. Biomaterials 2011;32:4857-4866. [PMID: 21486680][Impact Factor: 10.273] (cited by 89 times)
  57. Manna P, Das J, Ghosh J, Sil PC. Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IκBα/NF-κB, MAPKs and mitochondria dependent pathways: Prophylactic role of arjunolic acid. Free Radical Biology and Medicine 2010;48:1465-1484. [PMID: 20188823]Impact factor: 5.657] (cited by 102 times)
  58. Manna P, Das J, Ghosh J, Sil PC. Streptozotocin induced activation of oxidative stress responsive splenic cell signaling pathways: Protective role of arjunolic acid. Toxicology and Applied Pharmacology 2010;244:114-129. [PMID: 20053369][Impact factor: 3.585] (cited by 46 times)
  59. Ghosh J, Das J, Manna P, Sil PC. Hepatotoxicity of di-(2-ethylhexyl)phthalate is attributed to calcium aggravation, ROS-mediated mitochondrial depolarization, and ERK/NF-κB pathway activation. Free Radical Biology and Medicine 2010;49:1779-1791. [PMID: 20854900][Impact factor: 5.657] (cited by 41 times)
  60. Das J, Ghosh J, Manna P, Sil PC. Protective Role of Taurine against Arsenic-Induced Mitochondria-Dependent Hepatic Apoptosis via the Inhibition of PKCδ-JNK Pathway. PLoS One. 2010;7:5(9). [PMID: 20830294][Impact factor: 776] (cited by 52 times)
  61. Das J, Ghosh J, Manna P, Sil PC. Acetaminophen induced acute liver failure via oxidative stress and JNK activation: Protective role of taurine by the suppression of cytochrome P4502E1. Free Radical Research 2010;44:340-55. [PMID: 20166895][Impact factor: 2.825] (cited by 89 times)
  62. Das J, Ghosh J, Manna P, Sil PC. Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation. Toxicology 2010;269:24-34. [PMID: 20067817][Impact factor: 3.621] (cited by 77 times)
  63. Ghosh J, Das J, Manna P, Sil PC. Acetaminophen induced renal injury via oxidative stress and TNF-alpha production: Therapeutic potential of arjunolic acid.Toxicology 2010;268:8-18. [PMID: 19922764][Impact factor: 3.621] (cited by 73 times)
  64. Ghosh J, Das J, Manna P, Sil PC. Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection. Free Radical Biology and Medicine 2010;48:535-553. [PMID: 19969075][Impact factor: 5.657] (cited by 70 times)
  65. Ghosh J, Das J, Manna P, Sil PC. Protective effect of the fruits of Terminaliaarjuna against cadmium-induced oxidant stress and hepatic cell injury via MAPK activation and mitochondria dependent pathway. Food Chemistry 2010;123:1062-1075. [Impact factor: 5.399] (cited by 32 times)
  66. Manna P, Sinha M, Sil PC. Prophylactic role of arjunolic acid in response to streptozotocin mediated diabetic renal injury: Activation of polyol pathway and oxidative stress responsive signaling cascades. Chemico Biological Interactions 2009;181:297-308. [PMID: 19682444] [Impact Factor: 3.407] (cited by 51 times)
  67. Manna P, Sinha M, Sil PC. Protective role of arjunolic acid in response to streptozotocin-induced type-I diabetes via the mitochondrial dependent and independent pathways. Toxicology 2009;257:53-63. [PMID: 19133311][Impact Factor: 3.621] (cited by 60 times)
  68. Manna P, Sinha M, Sil PC. Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction. Amino Acids 2009;36:417-428. [PMID: 18414974] [Impact Factor: 2.520] (cited by 78 times)
  69. Sinha M, Manna P, Sil PC. Induction of necrosis in cadmium-induced hepatic oxidative stress and its prevention by the prophylactic properties of taurine. Journal of Trace Elements in Medicine and Biology 2009;23:300-313. (Equal contribution) [PMID: 19747626][Impact Factor: 2.895] (cited by 52 times)
  70. Mandal J, Manna P, Chakraborty P, Roy I, Gupta-Bhattacharya S. Clinical and immunobiochemical characterization of airborne Delonixregia (Gulmohar tree) pollen and cross-reactivity studies with Peltophorumpterocarpum pollen: 2 dominant avenue trees from eastern India. Annals of Allergy Asthma and Immunology 2009;103:515-24. [PMID: 20084846][Impact Factor: 2.599] (cited by 8 times)
  71. Roy A, Manna P, Sil PC. Prophylactic role of taurine on arsenic mediated oxidative renal dysfunction via MAPKs/NF-kappaB and mitochondria dependent pathways. Free Radical Research 2009;43:995-1007. [PMID: 19672740][Impact Factor: 2.825] (cited by 53 times)
  72. Ghosh J, Das J, Manna P, Sil PC. Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: Role of NF-kappaB, p38 and JNK MAPK pathway. Toxicology and Applied Pharmacology 2009; 240: 73-87. [PMID: 19616567][Impact Factor: 3.585] (cited by 107 times)
  73. Das J, Ghosh J, Manna P, Sinha M, Sil PC. Taurine protects rat testes against NaAsO2-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicology Letters 2009;187:201-210. [PMID: 19429265][Impact Factor: 3.499] (cited by 131 times)
  74. Das J, Ghosh J, Manna P, Sinha M, Sil PC. Arsenic induced oxidative cerebral disorders: Protection by taurine. Drug and Chemical Toxicology 2009;32:93-102. [PMID: 19514944][Impact Factor: 1.946] (cited by 47 times)
  75. Manna P, Sinha M, Sil PC. Cadmium induced testicular pathophysiology: Prophylactic role of taurine. Reproductive Toxicology 2008;26:282-291. [PMID: 18926901] [Impact Factor: 3.200] (cited by 46 times)
  76. Manna P, Sinha M, Sil PC. Amelioration of cadmium-induced cardiac impairment by taurine. Chemico Biological Interactions 2008;174:88-97. [PMID: 18561905][Impact Factor: 2.577] (cited by 51 times)
  77. Manna P, Sinha M, Sil PC. Protection of arsenic-induced testicular oxidative stress by arjunolic acid. Redox Report 2008;13:67-77. [PMID: 18339249][Impact Factor: 1.963] (cited by 67 times)
  78. Manna P, Sinha M, Sil PC. Arsenic-induced oxidative myocardial injury: protective role of arjunolic acid. Archives of Toxicology 2008;82:137-149.[PMID: 18197399][Impact Factor: 5.741] (cited by 126 times)
  79. Sinha M, Manna P, Sil PC. Terminaliaarjuna protects mouse hearts against sodium fluoride-induced oxidative stress. Journal of Medicinal Food 2008;11:733-740. (Equal contribution)[PMID: 19053867][Impact Factor: 2.020] (cited by 39 times)
  80. Sinha M, Manna P, Sil PC. Taurine protects the antioxidant defense system in the erythrocytes of cadmium treated mice. BMB Reports 2008;41:657-663. (Equal contribution)[Impact Factor: 2.966] [PMID: 18823590] (cited by 46 times)
  81. Sinha M, Manna P, Sil PC. Protective effect of arjunolic acid against arsenic-induced oxidative stress in mouse brain. Journal of Biochemical and Molecular Toxicology 2008;22:15-26. (Equal contribution)[PMID: 18273903][Impact Factor: 2.965](cited by 62 times)
  82. Sinha M, Manna P, Sil PC. Cadmium-induced neurological disorders: prophylactic role of taurine. Journal of Applied Toxicology 2008;28:974-986. (Equal contribution) [PMID: 18548748][Impact Factor: 3.065] (cited by 42 times)
  83. Sinha M, Manna P, Sil PC. Arjunolic acid attenuates arsenic-induced nephrotoxicity. Pathophysiology 2008; 15:147-156. (Equal contribution)[PMID: 18434106] (cited by 54 times)
  84. Ghosh J, Das J, Manna P, Sil PC. Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway. Toxicology In Vitro 2008; 22:1918-1926. [PMID: 18845235][Impact Factor: 3.067] (cited by 68 times)
  85. Das J, Ghosh J, Manna P, Sil PC. Taurine provides antioxidant defense against NaF-induced cytotoxicity in murine hepatocytes. Pathophysiology 2008;15:181-190. [PMID: 18676123] (cited by 46 times)
  86. Manna P, Sinha M, Sil PC. Protection of arsenic-induced hepatic disorder by arjunolic acid. Basic and Clinical Pharmacology and Toxicology 2007;101:333-338. [PMID: 17910617][Impact Factor: 2.452] (cited by 50 times)
  87. Manna P, Sinha M, Sil PC. Arjunolic acid, a triterpenoidsaponin, ameliorates arsenic-induced cyto-toxicity in hepatocytes. Chemico Biological Interactions 2007;170:187-200. [PMID: 17854788][Impact Factor: 3.407] (cited by 55 times)
  88. Manna P, Sinha M, Sil PC. Phytomedicinal activity of Terminaliaarjuna against carbon tetrachloride induced cardiac oxidative stress. Pathophysiology 2007;14:71-78. [PMID: 17611085] (cited by 22 times)
  89. Manna P, Sinha M, Sil PC. A 43 kD protein isolated from the herb Cajanusindicus L attenuates sodium fluoride-induced hepatic and renal disorders in vivo. BMB Reports 2007;40:382-395. [Impact Factor: 2.966] [PMID: 17562290](cited by 30 times)
  90. Manna P, Sinha M, Sil PC. Galactosamine-induced hepatotoxic effect and hepato-protective role of a protein isolated from the herb Cajanusindicus L in vivo. Journal of Biochemical and Molecular Toxicology 2007; 21:13-23. [PMID: 17366529][Impact Factor: 2.965] (cited by 19 times)
  91. Sinha M,Manna P, Sil PC. Taurine, a conditionally essential amino acid, ameliorates arsenic-induced cytotoxicity in murine hepatocytes. Toxicology In Vitro 2007;21:1419-1428. (Equal contribution) [PMID: 17624716][Impact Factor: 3.067] (cited by 55 times)
  92. Sinha M, Manna P, Sil PC. Attenuation of cadmium chloride induced cytotoxicity in murine hepatocytes by a protein isolated from the leaves of the herb Cajanusindicus L. Archives of Toxicology 2007;81:397-406. (Equal contribution). [PMID: 17262218][Impact Factor: 5.741] (cited by 25 times)
  93. Sinha M, Manna P, Sil PC. Aqueous extract of the bark of Terminaliaarjuna plays a protective role against sodium-fluoride-induced hepatic and renal oxidative stress. Journal of Natural Medicine 2007;61:251-260. (Equal contribution)[Impact Factor: 1.966] (cited by 41 times)
  94. Sinha M, Manna P, Sil PC. Amelioration of galactosamine-induced nephrotoxicity by a protein isolated from the leaves of the herb, Cajanusindicus L. BMC Complementary and Alternative Medicine 2007;7:11. (Equal contribution) [PMID: 17456244][Impact Factor: 2.479](cited by 27 times)
  95. Sinha M, Manna P, Sil PC. A 43kD protein from the herb, Cajanusindicus L., protects against fluoride induced oxidative stress in mice erythrocytes. Pathophysiology 2007;14:47-54. (Equal contribution) [PMID: 17403599](cited by 38 times)
  96. Manna P, Sinha M, Sil PC. Aqueous extract of Terminaliaarjuna prevents carbon tetrachloride induced hepatic and renal disorders. BMC Complementary and Alternative Medicine 2006;6:33. [PMID: 17010209][Impact Factor: 2.479](cited by 146 times)

 

Ramalingaswami Re-Entry Fellowship Grant, Title: Vitamin K as an adjuvant therapy for the prevention of insulin resistance and vascular inflammation in diabetes. Role:PI; Project Cost :32,50,000.00; Funding Agency: DBT; Duration: June, 2015 -May, 2020

Early Career Research Grant, Title: A novel therapeutic against metabolic syndrome via activation of coagulation unrelated vitamin K dependent proteins. Role:PI; Project Cost :31,63,968.00; Funding Agency:DST; Duration: April, 2018 -March, 2021

Will be undated soon

Interested students with can send their biodata throughout the year for doctoral and postdoctoral positions, post graduate dissertation work, and summer/winter training. Contact: pmanna2012@gmail.com